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Anticancers

Master GuideSign inAnticancer Agents — General Principles & ClassificationCancer and tumour genesis, how chemotherapy works, combination regimens, phase-specific drugs and the classes of anticancer drug.
Master GuideSign inAlkylating AgentsHow alkylating agents kill cells, the six classes, why tumours escape them, their signature toxicities and the busulfan extras.
Master GuideSign inAntimetabolites — Pyrimidine Analogues5-fluorouracil in depth, capecitabine, cytarabine and gemcitabine: the fluoropyrimidines against the cytidine analogues.
Master GuideSign inVinca Alkaloids & Platinum AgentsVincristine, vinblastine and vinorelbine, then the platinum agents: mechanism, kinetics, toxicity, uses and resistance.
Master GuideSign inCytotoxic (Anti-tumour) Antibiotics — Anthracyclines & OthersActinomycin D, the anthracyclines from daunorubicin to mitoxantrone, bleomycin and mitomycin.
Master GuideSign inEpipodophyllotoxins & Camptothecin Analogues — Topoisomerase InhibitorsTopoisomerase I and II: etoposide and teniposide, irinotecan and topotecan, trilaciclib, their toxicity and resistance.
Master GuideSign inHormonal Anticancer DrugsRemoving the hormonal drive: the antioestrogens and aromatase inhibitors for breast cancer, androgen deprivation for prostate cancer.
Master GuideSign inAnticancer Small Molecule InhibitorsKinase inhibitors by target, cell-cycle, DNA-repair, apoptosis and epigenetic inhibitors, mTOR and proteasome blockers.
Master GuideSign inAnticancer Monoclonal AntibodiesTargeted therapy and naming the antibodies: anti-EGFR agents, trastuzumab for HER2, and bevacizumab and aflibercept.
Master GuideSign inMiscellaneous Anticancer DrugsProteasome inhibitors, tyrosine kinase inhibitors, retinoic acid and arsenic, asparaginase, thalidomide, hydroxyurea and procarbazine.