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Antimicrobials

Master GuideSign inIntroduction to AntibioticsClassification and mechanisms, β-lactam structure, resistance, spectrum and safe empiric use, then every class in brief.
Master GuideSign inPenicillinsPenicillin G and V, the anti-staphylococcal, amino- and anti-pseudomonal penicillins, their harms, and β-lactamase inhibitors.
Master GuideSign inCephalosporins & CephamycinsMechanism and resistance, the four generations drug by drug, ceftaroline for MRSA, and the β-lactamase inhibitor pairings.
Master GuideSign inCarbapenems & MonobactamsImipenem with cilastatin, meropenem, doripenem and ertapenem, resistance and the carbapenemases, then aztreonam.
Master GuideSign inOther Cell Wall Synthesis InhibitorsThe polymyxins, vancomycin and teicoplanin, telavancin, dalbavancin and oritavancin, daptomycin and bacitracin.
Master GuideSign inAminoglycosides & SpectinomycinMechanism, resistance and the class toxicities, streptomycin to netilmicin one by one, and spectinomycin for gonorrhoea.
Master GuideSign inChloramphenicol, Clindamycin, Streptogramins, Oxazolidinones & PolymyxinsChloramphenicol, clindamycin, quinupristin-dalfopristin, linezolid and tedizolid, polymyxin B and colistin: uses and harms.
Master GuideSign inMacrolides & KetolidesErythromycin, clarithromycin, azithromycin, fidaxomicin for C. difficile, and the ketolides telithromycin and solithromycin.
Master GuideSign inQuinolonesDNA gyrase and topoisomerase IV, resistance, interactions and harms, then ciprofloxacin, levofloxacin and moxifloxacin.
Master GuideSign inSulfonamides & Related CompoundsThe folate pathway, the sulfonamides and their harms, then trimethoprim, co-trimoxazole, pyrimethamine and leucovorin rescue.
Master GuideSign inAnti-Tuberculosis DrugsIsoniazid, rifampicin, ethambutol, pyrazinamide and streptomycin, then the second-line drugs for multidrug-resistant TB.
Master GuideSign inAnti-Leprosy DrugsThe disease in brief, then dapsone, clofazimine and rifampin, and second-line ofloxacin, minocycline and clarithromycin.
Master GuideSign inAntifungal DrugsAmphotericin B, flucytosine, the azoles one by one, the echinocandins, griseofulvin, terbinafine and the topical antifungals.
Master GuideSign inAntiviral DrugsDrugs for herpes, CMV, influenza and hepatitis B and C, then HIV: NRTIs, tenofovir, NNRTIs, protease, integrase and entry inhibitors.